- • Careful monitoring is advised when considering stopping disease-modifying therapy (DMT).
- • Stopping DMT early in the disease course may be associated with an increased relapse rate.
- • Stopping DMTs may be considered if no new MRI lesions, a progressive disease course >5 years and age over 60.
Prolonged periods of disease quiescence during long term treatment of patients with clinically isolated syndrome and MS may prompt consideration of discontinuing disease-modifying therapy (DMT). We reviewed pertinent studies to identify the frequency and reasons for discontinuation of DMT.