Stopping immunomodulatory medications in MS: Frequency, reasons and consequences


• Careful monitoring is advised when considering stopping disease-modifying therapy (DMT).
• Stopping DMT early in the disease course may be associated with an increased relapse rate.
• Stopping DMTs may be considered if no new MRI lesions, a progressive disease course >5 years and age over 60.


Prolonged periods of disease quiescence during long term treatment of patients with clinically isolated syndrome and MS may prompt consideration of discontinuing disease-modifying therapy (DMT). We reviewed pertinent studies to identify the frequency and reasons for discontinuation of DMT.

via Multiple Sclerosis and Related Disorders.


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